HomeAbout LaminineSummary of Clinical Studies & Trials

Summary of Clinical Studies & Trials

Laminine Clinical Studies

Avian eggs are the golden standard of nutrients. It has proteins, lipids, vitamins, minerals, and growth factors, for the developing embryo, but it also contains defense factors that help protect against bacterial and viral infections.

Recent studies have revealed that eggs also contain biologically active components that go beyond their essential nutritional value.

Researchers have conducted extensive studies to identify and characterize these substances (Kovacs-Nolan J, Philips M, Mine Y).


The fertilized egg extract of Laminine and young tissue extract.

Laminine contains Fertilized Avian Egg Extract (FAEE), which is considered to be a better version of Young Tissue Extract. Dr. Bjodne Eskeland worked with both extracts.

The combination of FAEE in Laminine along with other peptides makes it an effective food supplement for activating dormant stem cells in the body.

The following summary of the clinical study reflects findings on YTE alone.

The new product is different from the original powder used in clinical work before 1999, with a ratio of 1:1.79. This means that 1.79 g of the old product is equivalent to 1 g of the current YTE™ product.

1. Effects on libido & depression

Initial experimental trials with the original Young Tissue Extract (YTE) product were conducted, but their results have not been reported.

Nevertheless, these trials provided a basis for anticipating potential properties of YTE, such as enhancing libido, improving stamina and muscle strength, enhancing mood, and other potential benefits.

The first structured studies were performed in 1992 (ref 1) to investigate the effects on sexual desire with a follow-up during 1992/93 (ref 2) with the same purpose. Both of these studies were double-blind, placebo-controlled studies.

These two studies were published in an article in the Journal of International Medical Research in 1997 (ref 4), together with the conclusions of an open post-marketing study performed in Sweden (ref. 3).

This last study supports the findings of the two placebo-controlled studies. Still, it cannot be used as documentation alone.

As it is known that antidepressant medication often leads to decreased sexual lust and performance, a small pilot study in patients on antidepressant medication (SRI) for a minimum of 6 weeks was performed in Denver, Colorado, during 1996/97.

Although a small sample size, this study gave statistically significant results. It is believed that the increase in serotonin levels was enough to induce a sense of happiness (Ref 5)

At the same time, an animal study was performed in Japan to study the effects on the sexual behavior of YTE™ in rats.

The results of this study are consistent with the findings in the human studies – further documenting the findings that YTE™ has a stimulating effect on sexual desire and behavior. (ref. Pre-clinical trials)

In two clinical studies conducted on YTE for stress and antidepressant, it was found that YTE can help in adapting to acute stress by normalizing the endocrine and subjective stress response.

The studies also suggested that YTE can be used as a supplement to drug treatments in the treatment of mood disorders.

Additionally, YTE has been shown to enhance the effects of creatine, which can be beneficial for individuals who engage in exercise and muscle building. Furthermore, the Norwegian Army study indicated that YTE alone could improve muscle strength and recovery time.

According to the Academy of Sports study, YTE™ was found to affect cortisol levels in the blood and the cellular uptake of testosterone.

There is also significant evidence from clinical and animal studies to support the notion that YTE™ has a stimulatory effect on sexual desire and behavior in both the general population and in individuals who experience a decrease in sexual desire due to the use of antidepressant medication.

Laminine Side effects

There are no known Laminine side effects except when a person has allergic reactions to eggs. Although in some conditions where side effects may arise, the benefits of Laminine, such as CKD or Cancer, the protein FGF is most beneficial in helping cells or organs repair themselves.

Effects on Stress (Anti-stress)

This study was designed to ascertain the effect of the nutritional supplement, Laminine on cortisol levels in the body. During the experiment, 28 subjects, 16 women and 12 men, between 36 and 83, participated.

Each participant’s salivary cortisol level content was measured before they took part in the survey. This figure is known as the “pre-Laminine usage level.”

The salivary cortisol level was also measured every fifth day three times throughout the study when each participant’s intake amount was changed.

Overall, study participants’ cortisol levels were reduced by an average of 23.7 percent, where 16 started on a higher intake of Laminine—four capsules, twice a day—and 12 began on one pill twice per day.

Participants that initially started on higher information of Laminine saw their cortisol level reduced significantly over the first four days compared to subjects that began the study with a lower usage amount.

However, at the end of the study, there was a small, although insignificant, difference in favor of the high initial intake.

Effects on muscle repair

In order to study the effects on physical performance, muscle size etc a study was performed during the same period – also in Denver, Colorado.

As creatine is widely used among bodybuilders, this substance was used as the placebo treatment, while a combination of YTE™ and creatine was used as active treatment.

As the effects of creatine are known, this study can be regarded as a test against creatine (as a placebo) and no treatment (given the documented impacts of creatine).

The result showed that the addition of YTE™ gave a significant increase in motivation (mental effect) and a non-significant improvement in strength and muscle size.

On this basis, we can conclude that YTE™ tends to increase the effects of creatine in bodybuilding, i.e., a positive impact on strength and muscle size. (Ref. 6)

Effects on hormones

A hypothesis established that the clinical effects seen were due to hormonal effects. A study of the hormonal effects was subsequently performed in Oslo, Norway, into the hormonal effects of a single dose of YTE™.

The purpose of this study was to investigate the hormonal changes resulting from a high single dose of YTE™. The results suggest that YTE™ may have a significant impact on reducing cortisol levels and enhancing the cellular uptake of testosterone.

These hormonal effects could potentially contribute to the observed clinical effects. (Reference 7)

Another Laminine clinical study was performed during the same period on 14 Norwegian Armed Forces elite soldiers into muscular strength, restitution time,, and quality of life.

Still, the details of this study are missing. (At the time, Med-Eq was only partially involved in the process.) Further studies Med-Eq has sponsored two studies into the mood-enhancing properties of YTE™.

These studies use the presently recommended dosage of four YTE capsules per day of 420 mg each.

Effects on memory

Several studies have also been performed into the effects on memory enhancement, and the results of these studies are under processing to submit to publications.

Effects on wound healing

The authors suggest that the amino acid entry into the cell through peptide transporters is a more efficient way to stimulate protein synthesis than the entry of amino acids alone.

They also propose other mechanisms that could explain the increased wound healing observed with peptide diets compared to nonpeptide diets, including the stimulation of collagen synthesis, increased blood flow to the wound, free radical scavenging, and generation of cytokine profiles that better support wound healing.

laminine clinical studies

Advances in the value of eggs and egg components for human health.

The study cited (J. Agra Food Chem. 2005; 53:8421-31) describes YTE™ as a patented extract from fertilized, partially incubated hen eggs that is obtained by separating oligopeptides from the total mass.

These oligopeptides have molecular weights of 0.5 – 1.8 kD, which allows them to pass freely through the digestive barrier.

These embryonic peptides work via elevating 17-ketosteroid levels in the adrenal glands, improving anabolism through increased synthesis of androgens, and decreasing the catabolic hormone cortisol, which offers multiple benefits.

Initially, a less processed powder using the full content of the egg (excluding the shell) was used. The administration was in powder form in sachets.

The taste of the product was not considered acceptable to the public. Later (from 1999), inactive parts were separated before further processing, providing a more concentrated powder.

This was first planned for tablet use, but putting it in tablet form proved difficult due to hygroscopic properties. Hence, Laminine in capsule form is most effective in preserving the peptides.

The current version of the YTE™ product, which is available in hard-gel capsules, has been available for purchase since 2001.

Click here for PDR clinical studies on Laminine & Laminine Omega+++
Click here to download clinical studies

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