How FGF2 can affect Amyotrophic lateral sclerosis

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DISCLAIMER: Laminine is not a cure for this type of disease or sickness. This article is merely showing through external studies how FGF2 (in Laminine), can positively affect the condition.


How FGF2 can affect Amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS or Lou Gehrig’s disease) is a disorder that involves the death of neurons that control voluntary muscles.[1]. ALS is characterized by stiff muscles, muscle twitching, and gradually worsening weakness due to muscles decreasing in size. This results in difficulty speaking, swallowing, and eventually breathing.[2]

The cause is not known in 90% to 95% of cases.[1] About 5–10% of cases are inherited from a person’s parents.[3] About half of these genetic cases are due to one of two specific genes. The diagnosis is based on a person’s signs and symptoms with testing done to rule out other potential causes.[1]

No cure for ALS is known.The disease usually starts around the age of 60 and in inherited cases around the age of 50.[3] The average survival from onset to death is three to four years.[4] About 10% survive longer than 10 years.[1] Most die from respiratory failure.

Prolonged survival and impairment of motor function

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective motoneuron loss in brain and spinal cord. The cause for the selective death of motoneurons is still unclear. Basic fibroblast growth factor 2 (FGF-2) plays a prominent role in the motor system but to date, there are no conclusive results that shows it can positively affect patient with ALS.

Other studies concluded that FGF-2 may be a useful treatment to provide neuroprotection against neurodegeneration in amyotrophic lateral sclerosis (ALS) by encouraging the proliferation of NPCs and delaying the decrease in the density of S-IR boutons.[5]

Laminine Food Supplement which contains FGF2 and amino acids however can still affect patients with ALS by providing the energy and hope that it can somehow help in the repair or prolong the impairment of the motor function, that affects the muscle.

[1] Amyotrophic Lateral Sclerosis (ALS) Fact Sheet”. National Institute of Neurological Disorders and Stroke 2014.
[2] ALS (Wikipedia)
[3] NCBI: A comprehensive review of amyotrophic lateral sclerosi
[4] Clinical neurology of the older adult
[5] Mechanism of neuroprotective effects of fibroblast growth factor 2 in the mouse model of ALS

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