HomeAbout LaminineEffects of Laminine on Blood Sugar

Effects of Laminine on Blood Sugar

Study on how Laminine affects blood sugar levels

Dr. Edward Andujar, M.D.
A study performed in fall 2014 – winter 2015

12-Weeks Study

A pilot study examined the potential trend of Laminine, a dietary supplement, in normalizing blood sugar levels in subjects with initial signs of unhealthy blood sugar levels. This study assessed the subjects’ Hgb A1c, a hemoglobin marker for blood sugar levels, at the beginning of the study and after 12 weeks of taking two supplements daily.

Eleven individuals participated in the study. Three subjects took a placebo, and four with slightly higher than normal Hgb A1c levels took two Laminine daily. Four issues on blood sugar-lowering medications previously prescribed for them took two Laminine daily.

Although sample sizes were small, statistical evaluation using matched pairs and T-test showed that the group experiencing slightly higher than normal blood sugar levels were significantly down-regulated with supplementation.

Normalizing blood sugar levels

The unit change in the down-regulation of blood sugar was also statistically significant. No significant difference was observed in the group taking blood sugar medication with supplements.

The results indicated that Laminine supplementation may have supported normalizing blood sugar levels in individuals experiencing higher-than-normal blood sugar levels.

A study is warranted to observe this effect in a larger population. No untoward side effects were observed in either group supplementing with Laminine for 12 weeks.

Measuring the results

The Hgb A1c test was chosen to measure the effects of Laminine on normal blood sugar levels as opposed to other blood sugar tests because of its accuracy.

Hgb A1c measures the percentage of hemoglobin (a protein in red blood cells that carries oxygen throughout the body) coated in sugar (glycated hemoglobin) over the previous 60-90 days.

Therefore, it is not affected by short-term glycemic fluctuations (heavy meals, medications, etc.) that may impact the accuracy of other tests. The study lasted 12 weeks (84 days) to measure changes in Hgb A1c levels correctly.

Normal/healthy Hgb A1c levels are 5.6 percent and below, and Hgb A1c levels between 5.7 to 6.4 percent may indicate an increased risk for unhealthy blood sugar levels. Hgb A1c levels of 6.5 percent or above may indicate harmful blood sugar levels.

As the difference between healthy blood sugar levels and an increased risk for unhealthy levels can be as minute as 0.1 percent, even a slight drop in Hgb A1c levels proves beneficial for maintaining regular blood sugar.

Although metabolic syndrome was primarily a condition of middle-aged populations, it is becoming a condition of children, adolescents, and young adults worldwide.

  1. Its criteria are overweight, sedentary lifestyle, and “modern diets” of too much food and poor lifestyle habits. Obesity, part of the metabolic syndrome, is the fastest-growing health-related problem worldwide. The urgent need for preventive measures to reduce the significantly increased health risk is underscored.
  2. The metabolic syndrome comprises a cluster of cardiovascular risk factors that increase the risk of future coronary heart disease, type II diabetes, and stroke.
  3. The prevalence varies between countries but runs about 20 percent in most westernized cultures (i.e., 24 percent of the middle-aged population in Europe).
  4. Lifestyle has been closely associated with the development of metabolic syndrome, with diet and physical activity identified as two of the most important modifiable lifestyle factors, in this regard.

After 12 Weeks

One of the three random participants in Group A experienced no change in Hgb A1c levels, while the other two saw their grades rise over the 12 weeks.

Each of the four participants in Group B (Laminine) experienced a down-regulation in Hgb A1c levels after 12 weeks, with the the greatest normalization exhibited in participant B2.

GROUP A (Placebo)
GROUP B (Laminine)
METHODS (continued)

The dietary supplement, Laminine, is a proprietary blend of Fertilized Avian Egg Extract, Phyto, and marine proteins. This combination provides the body with all 22 amino acids, including the essential and non-essential required for protein synthesis.

Group A took one placebo in the morning and one in the evening. Group B took one Laminine capsule in the morning and one in the evening.

Participants in Group C took one Laminine capsule in the morning and one in the evening in addition to their blood sugar medication.

  • All of the participants in Group C were taking their blood sugar medication before participating in the study.
  • Participants in this group were on as few as one and as many as three different drugs during the study.
  • These medications included insulin and oral medications.

GROUP B and the two groups receiving Laminine were tested initially at week 0 before administration of a placebo or dietary supplement and then at week 12.

  • Neither diet nor exercise was monitored during the study period.
  • Participants with Unhealthy Blood Sugar Taking no Medication
  • Received Two Placebo Tablets Twice Daily (n=3)

Four subjects with unhealthy blood sugar were taking previously prescribed medication. They received two tablets of Laminine daily (one in the morning and one in the evening). Participants with Unhealthy Blood Sugar Taking no Medication Received two Laminine capsules twice daily showed statistical significance in blood sugar down-regulation (n=4).


Participants with Unhealthy Blood Sugar Taking Previously Prescribed Medication Received two Laminine pills twice daily showed no statistical significance in blood sugar down-regulation (n=4). Results showed statistical importance in blood sugar down-regulation.

The change in unit value (0.475) was also statistically significant. Results did not show statistical significance in blood sugar down-regulation.


The four subjects in Group B (at risk for unhealthy blood sugar levels) consuming two Laminine daily were evaluated using two sample matched pairs T-test with a significant result (p=0.0273). Using one sample test, only on the differences, there was an average change of 0.475, which was also substantial (p=0.0382).

The group of subjects experiencing blood sugar levels controlled by medication (Group C) consuming two Laminine daily was also evaluated using two sample matched pairs T-test with no significant results. Both statistical evaluations assumed the data was normally distributed. Subject groups were tiny, but each subject had measurements taken before and after 12 weeks of supplementation; therefore, these differences could be evaluated.


Metabolic syndrome often shows increasing levels of glucose intolerance. Measures to support persons who are overweight, have sedentary lifestyles, and are showing higher than normal glucose levels but are not classified as diabetic could benefit from taking Laminine.

Although the sample size was small, this preliminary investigation did show a significant difference between glucose levels before and after 12 weeks of supplementation with Laminine.

The difference in the Hgb A1c marker measurements before and after supplementation (a change of 0.475 units) was also statistically significant in Group B, adding credence to the noted effect.

This preliminary evaluation shows the possibility that this supplement may have a beneficial effect towards helping maintain average blood glucose in subjects at risk for developing high blood glucose and warrants further study with a larger population.

The statistical evaluation of Group C individuals taking medicines for normalizing high blood glucose levels illustrated the supplement’s safety as it did not interfere with medication or significantly alter the measurements as a group. Only one subject showed a higher-than-lower effect while on the addendum.

However, one participant in Group C had been taking insulin with Laminine at the start of the study. Per this participant’s physician’s recommendation, they had utterly tapered off the insulin and maintained stable blood sugar levels by the conclusion of the 12 weeks.

All participants in Group B experienced a normalized down-regulation in Hgb A1c levels, and three out of the four participants saw a positive change in their stories in Group C.

It is known that nine-day fertilized avian egg extract that is not denatured with heat processing could retain fibroblast growth factor (FGF) activity. Because growth factors react with receptor sites on somatic cells, this activity could support glucose absorption.

Laminine also contains fish and vegetable protein, which may affect glucose tolerance when added to the diet continuously.

Continuing studies are warranted on clinical effectiveness and the mechanism of action of Laminine.

1 Ekelund U, Anderssen SA, Froberg K, Sardinha LB, Andersen LB, Brage S, et al. (2007) Independent associations of physical activity and cardiorespiratory fitness with metabolic risk factors in children: the European youth heart study. Diabetologia 50: 1832–1840.
2 Healy GN, Matthews CE, Dunstan DW, Winkler EA, Owen N (2011) Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003–06. Eur Heart J 32: 590–597.
3 Elin Ekblom-Bak, Annika Rosengren, Mattias Hallsten, Göran Bergström, and Mats Börjesson. Cardiorespiratory Fitness, Sedentary Behaviour, and Physical Activity Are Independently Associated with the Metabolic Syndrome, Results from the SCAPIS Pilot Study. PLoS One. 2015; 10(6): e0131586.

→ Understanding how Laminine works on blood sugar.
→ Testimony on diabetic patients taking Laminine.

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