HomeAbout LaminineFull Prescribing Information

Full Prescribing Information

Summary of clinical study of Laminine, published at Prescribing Desk Reference (PDR®)

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Among the drugs and supplements listed on PDR.net is Laminine Food Supplement, recorded since 2014.

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General Information on Laminine

Laminine Ingredients

OPT9 Proprietary Blend at 620 mg. The proprietary formula in Laminine is called OPT9™. This formula comprises three (3) ingredients: Fertilized Avian Egg Extract (FAEE), Phyto Proteins, and Marine Proteins. Other Ingredients: Laminine contains inactive carriers: Vegetable Capsules, Silicon Dioxide, and Magnesium Stearate.

Product Description of Laminine

Laminine contains the proprietary process of FAEE and a blend of marine and Phyto proteins added to make it unique with all essential amino acids.

Technical Description of Laminine

For centuries, people have recognized the health benefits of hen eggs. Further research into the mechanisms behind egg development after fertilization has also revealed specific health benefits.

In earlier studies, while monitoring the weight gain of the egg during their development, scientists found minimal gain in the first 9-10 days (7.5%) and then a sharp increase (1190% by day 23), suggesting the rapid development of a body.

FAEE Potency

The potency of the nutrients available to the fertilized avian egg at this stage has always been assumed to be high. Still, it was only recently that the chemical structure of the original egg solids for these critical stages, termed blastodermal to proto-embryonic steps, was obtained.

During the blastodermal to proto-embryonic stages of embryogenesis, oligopeptides with molecular weights from 0.5 to 1.0 kD were identified. Oligopeptides are compounds with 2 to 20 amino acids joined by a peptide bond.

FGF and amino acids peptides

These short chains of amino acids can cross the digestive barrier without breaking down or changing the ratios and proportions (2).

Peptides are far more potent than other neurotransmitters, requiring only small amounts to produce a profound effect.

Additionally, the uptake of the Fibroblast Growth Factor (FGF) (present in the proto-embryonic fluid) and other bioactive peptides by the developing avian egg sharply increases between days 11 & 12.

These peptides and the FGF have been isolated through a proprietary process precisely at the right stage of development, using a proprietary drying technique to bring health benefits to humans. The extract is termed Fertilized Avian Egg Extract.

Dr. John R. Davidson

In 1929, John R. Davidson, a Canadian Doctor, discovered an extract derived from fertilized avian eggs when they were at a critical stage of development.

He used this extract to restore the health of his patients. Dr. Davidson spent well over a decade developing and researching his theory.

However, when Dr. Davidson passed away in 1943, his research on fertilized avian eggs was not passed on and was soon forgotten.

Nearly 50 years later, the pursuit of fertilized avian egg extract was revived by Norway’s foremost expert on egg research: Dr. Bjoedne Eskeland.

He took Dr. Davidson’s original research a step further. He hypothesized that fertilized avian eggs contained a unique combination of amino acids, peptides, and protein fractions that could help provide an incredible array of health benefits when consumed by humans.

This included vitamins, minerals, proteins, essential defense elements, growth factors, hormones, and other biologically active components.

Mechanism of Actions

The bioactive peptides in Laminine stimulate the dormant stem cells to utilize the Phyto amino acids and marine protein to repair damaged aged cells.

Drying the proto-embryonic fluid before the peptides are “used up” to build organs and bones allows us to provide this building, repairing, and maintenance mechanism of perfectly balanced amino acids, peptides, and growth factors to humans.

Nature has devised an extremely versatile mechanism to provide nutrition with miraculous precision to the embryo of living creatures.

The precise blend of oligopeptides may be seen as building blocks without a bridge or a director.

The role of such a director is fulfilled by a growth factor known as the Fibroblast Growth Factor, or FGF, also a bioactive peptide. FGF is prolific in proto-embryonic liquid as well as the human placenta.

Bioactive peptides stimulate the dormant stem cells to utilize the phyto amino acids.

Bioactive peptides in the embryo

On the 11th day of the incubation cycle of a chicken egg, the chicken tissue shows a steep increase in these bioactive peptides, with the appropriate peptides to form the solid organs and bones (3).

A detailed day-by-day study was performed in 1988 (5; 7).

Discovered only in the seventies, FGF and bioactive peptides are critical in developing embryos, including humans.

Bioactive peptides are responsible for building the linings in the blood vessels, creating the infrastructure for the nutrients to flow to critical areas of the brain and organs.

Research credits bioactive peptides with the potential to directly affect many neuro disorders because of the precise results of bioactive peptides’ ability to influence the growth of neurites (4).

Neurites are signal senders (Axons) and signal receivers (dendrites) attached to the brain neurons.

Research has also shown that new cell cultures show a dramatic increase in peptide and amino acid uptake in the presence of FGF.

This result gives credence to the hypothesis that embryonic growth is influenced by the ant mechanism, which that unique combination of amino acids, peptides, and FGF.

General Benefits of Laminine

The beneficial impacts of Laminine are positive effects on memory, skin, libido, energy, joints, muscles, stress, sleep, and emotional stability.

Recently, a new study indicated Laminine’s positive effect on encouraging telomeres to regenerate, aiding osteoarthritis joint pain due to aging.

Additionally, a previous study on normal blood sugar makes Laminine an ideal food supplement for prediabetics.

Click here for a complete list of Laminine benefits.
Click here for known side effects of Laminine.

Clinical and experimental studies

Laminine on Wound Healing Activity

In a 1997 study, immediately following surgery, (animal) subjects were randomized to receive either an amino acid diet or a peptide diet for ten days, and the strength of the wound was measured.

Wound bursting pressure was significantly higher in subjects receiving the peptide diets than those receiving amino acid diets.

The authors suggest that dietary peptides may stimulate the production of growth factors such as growth hormone, insulin, or insulin growth factor (IGF-1).

They also postulate that the amino acid entry into the cell via peptide transporters may be more efficient for stimulation of protein synthesis than an entry in the form of just amino acids.

Other possible mechanisms suggested by the authors for the increased wound healing with peptide versus non-peptide diets include stimulation of collagen synthesis, increased blood flow to the wound, free radical scavenging, and generation of cytokine profiles which better support wound healing.

Laminine on Cortisol (Stress hormone) Study

This study was designed to ascertain the effect of the nutritional supplement, Laminine on cortisol levels in the body.

During the experiment, 28 subjects, 16 women and 12 men between 36 and 83 participated. Each participant’s salivary cortisol level content was measured before taking part in the survey.

This figure is known as the “pre-Laminine usage level.” The salivary cortisol level was also measured every fifth day three times throughout the study when each participant’s intake amount was changed.

laminine stress hormone cortisol

Overall, study participants’ cortisol levels were reduced by an average of 23.7 percent, where 16 started on a higher intake of Laminine—four capsules, twice a day—and 12 began on one pill twice per day.

Participants that initially started on a higher intake of Laminine saw their cortisol level reduced significantly over the first four days compared to subjects that began the study with a lower usage amount.

However, at the end of the study, there was a small, although insignificant, difference in favor of the high initial intake.

The total cortisol reduction by the end of the study was 27.3 percent in women and 19.2 percent in men.


Laminine on Cholesterol and Blood Pressure Studies

The study was designed to test the effects of the nutritional supplement, Laminine, independently and in combination with Laminine OMEGA+++, on cholesterol, low-density lipoproteins (LDL), high-density lipoproteins (HDL), triglycerides, and blood pressure.

There were 15 individuals in the study, broken into three groups of five. This was a double-blind, placebo-controlled study that took place over a total period of 12 weeks.

Groups A, B, and C on cholesterol profile

The study took place in two phases. The first lasted eight weeks and included Groups A, B, and C. Cholesterol serum profiles and blood pressure were taken from participants in each group at the start of week one and the conclusion of week eight.

During this study phase, participants took four supplements daily—two in the morning and two in the evening.

Second phase study

The second phase of the study only included participants from Group A and lasted an additional four weeks, after which time cholesterol serum profiles were measured again.

During phase II, participants in Group A consumed eight supplements a day—four in the morning and four in the evening.

During the first phase of the study, results showed that the average cholesterol drop in Group B was about 9.8 percent, compared to 11.5 percent in Group C.

Meanwhile, cholesterol levels in Group A increased by 1.0 percent over the first eight weeks but dropped by 12 percent between weeks eight and 12. Results for LDL and triglycerides generally followed a similar pattern.

laminine clinical studies triglycerides cholesterol

Subjects in Group A were also given a subjective survey after Phase II when they were asked to rate improvement in their joints, memory, skin, sexual drive, muscle tone, strength, stress levels, sleep, and emotional well-being.

Only four of the five subjects in Group A chose to participate in the survey. After Phase II, the average improvement in all categories was about 5.75 on a scale of 0-10, with zero representing no change and 10 representing a significant improvement. These are subjective results but notable.

laminine clinical studies review

Laminine on Cholesterol and Blood Pressure Studies Discussion

Triglyceride levels in Group A dropped by 267 mg/dl or 58.2 percent during Phase II, the most substantial change throughout the study. However, participants in Group C experienced the best and most consistent overall results.

HDL levels were within normal limits at the beginning and end of the study for all participants.

Although participants in Group A took double the Laminine and Laminine OMEGA+++ during Phase II, results were not drastic enough to recommend doubling the suggested usage for Laminine OMEGA+++ for all individuals.

The decrease in LDL was not significant in Group A during Phase II compared to Group C during Phase I.

triglyceride cholesterol high blood

Nevertheless, for individuals with high triglycerides, doubling the intake of Laminine and Laminine OMEGA+++ can yield a drastic improvement in a short period.

From these data, we can conclude that Laminine OMEGA+++ helps to lower cholesterol, LDL and triglyceride, and blood pressure levels (Group B).

Still, when taken with Laminine, the decreases are more significant (Group C after Phase I and Group A after Phase II).

From these data, we can conclude that Laminine OMEGA+++ helps to lower cholesterol, LDL and triglyceride and blood pressure levels

Laminine on Safety

People with egg allergies should consult a physician before taking Laminine®. Pregnant women should consult with a physician before taking Laminine®.

Laminine is not intended to replace medication. It is not a cure for diseases.


Roberts, Pamela R, et al. Nutrition Vol. 14, No. 3, 1998.
Arvanitakis, Constantine. Am. Jour. of Physiology, Vol. 231, No. 1, July 1976.
Joseph-Silverstein, Jacquelyn, et al. (June 1989) Basic Fibroblast Growth Factor in the Chick Embryo: Immunolocalization to Striated Muscle Cells and Their Precursors. The Journal of Cell Biology, 108: 2459-2466.
Hatten, M. E., et al. (1988) In Vitro Neurite Extension by Granule Neurons is Dependent upon Astroglial-Derived Fibroblast Growth Factor. Developmental Biology, 125:280-289.
Seed, Jennifer, et al. (1988) Fibroblast Growth Factor Levels in the Whole Embryo and Limb Bud during Chick Development. Developmental Biology, 128:50-57.
Gospodarowicz, D, et al. (1986) Molecular and Biological Characterization of Fibroblast Growth Factor, an Angiogenic Factor Which Also Controls the Proliferation and Differentiation of Mesoderm and Neuroectoderm Derived Cells. Cell Differentiation, 19: 1-17.
Seed, Jennifer, et al. (1988) Fibroblast Growth Factor Levels in the Whole Embryo and Limb Bud during Chick Development. Developmental Biology, 128:50-57.

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  1. I was reading a negative comment on Dr sukala and believed him until I read this clinical study. Thank you. I am releaved now when a colleague told me it worked and helped her recover.


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