Laminine & the stem cell architect, FGF
What is FGF or Fibroblast Growth Factor?
FGFs activate existing stem cells in the body to maintain or repair aging cells, tissues, muscles, or nerves and exhibit stem cell-like properties.
The fibroblast growth factor (FGF) family of growth factors plays a crucial role in the physiology and function of various organs and systems in the body.
Spine
Brain
Sex organs
Blood vessel tone
Body muscle and heart muscles
Nasal passages
Nerve coordination
Bone mineralization.
In addition, FGFs are also involved in vitamin D utilization, which is essential for maintaining bone health and other physiological processes.
- Fibroblasts are essential in the growth and differentiation of various cell types in the body.
- High amounts of FGFs are present during the embryonic stage until full fetal development.
- It dissipates as humans or animals come to full maturity.
The stem-cell-like function of Laminine
FGF and Amino Acids
FGF, along with amino acids, are critical for biological processes. FGFs bind to specific receptors on the surface of cells that triggers biochemical reactions for cell growth, healing, and proliferation.
Amino acids, which Laminine also has, are necessary for FGFs to initiate stem cell repair, depending on a specific FGF isoform and the type of stem cells involved.
At the same time, FGFs have a conserved sequence of amino acids (FGF core) that facilitates binding to receptors and triggering signaling pathways for regeneration.
The stem cell-like function of Laminine is found in the combination of marine proteins and comes from FGF2 in PESE that make up the OPT9 formula.
FGF may be combined with other growth factors (and subtypes such as cytokines) as part of a treatment protocol. Therefore their infusion is essential before stem cell therapy.
Extracting fibroblast growth factor for commercial use as injectable vials may involve exacting it from animal tissues or even human placenta but with ethical issues.
Even though Laminine is not intended as a preparation for stem cell treatment or marketed as a stem cell supplement, as a food supplement, it has demonstrated healing properties, benefits, and positive results.
FGF is an active ingredient found in Laminine.
In 1929, Dr. John Ralston Davidson discovered an egg extract resembling growth factors’ behavior. It took decades to improve it by other scientists, creating the OPT9 blend of Laminine.
Laminine food supplement carries complex marine and soy proteins and FGF2 conveniently in powder capsule form.
COMPLETE INGREDIENTS OF LAMININE.
Why is FGF important to healthy aging
In the evolution of stem cell therapy, growth factor infusion is a critical preparation before treatment. Without signaling proteins such as FGFs, the stem cells in the body will not know what to do or where to go.
FGFs are proteins that signal cells in the body to mobilize, differentiate, and execute the repair of damaged or aging cells. It’s essential for many biological processes, including tissue development, wound healing, and nerve and cell maintenance.
A recent study demonstrated that protein components in Laminine, such as FGF2, can boost telomerase activity, leading to telomeres’ restoration. As a result, this can alleviate joint pain by repairing telomere caps (aglet-like ends of the strands of DNA called chromosomes).
We know this because an FGF2 gene transfer restores hippocampal functions and has therapeutic implications for neurocognitive disorders. [PNAS]
A study suggests gene therapy with FGF2 is effective in potentially ameliorating cognitive dysfunction after the onset of symptoms.
However, Laminine is NOT a gene therapy, but the finding opens many possibilities when it comes to taking food supplements that have positive consequences for brain health.
Someone emailed me and said Laminine no longer produced its FGF from Avian egg whites. Apparently, a U.S. company produced a substitute and Laminine decided to use it.. This is supposed to have happened in 2012. Your website was dated 2014.
Cab you shed some light about this for me?
Larry Maheu June 30, 2015
Since early 2012, LifePharm Global Network has sourced its Fertilized Avian Egg Extract from organic, cage-free, hormone-free chicken farms in the United States, which is then developed with the process of Hygienic Evaporative Cooling. Hygienic Evaporative Cooling keeps the peptide chains that are so important in Laminine intact when converting the Fertilized Avian Egg Extract from a liquid to a powdered form. This technology is exclusive to LifePharm Global Network and was not readily available anywhere else in the world besides the United States. Previously, LPGN sourced its Fertilized Avian Egg Extract from Norway, but the change occurred in order to ensure the quality, traceability and supply of our materials. The laws governing avian products are especially stringent in the U.S.A., and LifePharm Global Network prides itself on operating under FDA and cGMP guidelines. You can find the answer to this, and other common questions here: https://altheadistributor.com/downloads_materials/ENG-Laminine-FAQ.pdf
Hi there, I am a bodybuilder and FGF is listed as a banned substance for natural competitions. I have approached Lifepharm for clarification on the FGF content in Laminine and how long it stays in the body as clearly I cant risk having FGF in my urine if tested. However they have declined to assist me. Can you provide any guidance on this subject? How far out should I stop taking Laminine? Or indeed is it detectable? Thanks in advance. Jane
World Anti-Doping Agency prohibits any form of drug or chemical substance that will cause an athlete to have the edge, simply because he/she has access to these expensive aids for muscles gain in general. This can also refer to FGFs in vial, injectable form. This potent form of FGF is traceable and comes as a form of treatment to activate stem cells in the body. Laminine’s FGF form part of the egg peptides/protein/amino acids, it is food in form, much like how vitamins work. The FGF in Laminine is not synthesized and is naturally produced in a partially incubated egg. Thus Laminine should NOT be classified as one and the same with injectable FGF that anti-doping agency prohibits. To begin with, the potency is much different. On a personal note as to traceability, I believe it is difficult to quantify because you take Laminine as food, incorporated with your diet. Laminine can also be classified as as dietary supplements which is encouraged by USDAA, and not listed in the USAAD prohibited list.
Did you ever get a clearer answer to this question in terms of testing/potency? Going into weightlifting competitions next year, and have taken Laminine for almost 4 years, and I still see FGF on the prohibited substances list.
The FGF WADA is referring to is the injection form of FGF, those that are used for direct stem cell transplant. Laminine’s ingredient list does not specifically say FGF since it’s not there in its purest form. Rather, the FibroBlast GF (in lesser quantity as compared to FGF injection) is naturally found in the egg’s protein synthesis (The mine-days Fertilized Avian Egg Extract). In terms of potency, the injection will supersede the food supplement. Laminine works for general cellular repair because of its combination with other ingredients.
To say that the human body does not produce FGF is incorrect – the body produces 22 types of FGF. Which raises another issue: when you state that laminine contains FGF, which FGF are you referencing? As mentioned previously, humans produce 22 different FGF peptides that are produced by different tissues, signal through different receptors and exert different effects on different cell types.
Referring to the 22 members of the FGF family that have been identified, although these are structurally related to signaling molecules (amino acids found in the body), the best source will still be through diet/food because the body (adults) can no longer make a significant amount of these, as compared to fetus or infants, where FGF/angiogenesis is required.
Laminine’s FGF2 (family of growth factors) has been found in other animals such as cows, and in the case of Laminine, extracted from partially incubated hen egg, that has the highest quality of FGF known to science to date. Although the basic fibroblast growth factor (FGF-2) in the hypothalamic-pituitary system can be found, the expression of FGF-2 mRNA in the pituitary is low; the protein is widely distributed in both its neural and anterior lobes. Thus when the egg extract (Laminine) was discovered (also known as YTE), the supply through a diet of these proteins (rich in FGF2), has to come through a supplement. We know this based on clinical studies that show the ingestion of supplement rich with FGF(2), has greatly affected cells to heal more rapidly, than a person just eating healthy food.
We do take note of rephrasing the article if it insinuated that the body cannot produce FGFs altogether. Thank you.