Laminine & the Stem Cell Architect, FGF

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How is FGF helpful to humans?

The precise blend of oligopeptides may be seen as building blocks, without a bridge, or a director. The role of such a director is fulfilled by a growth factor known as the Fibroblast Growth Factor, (repair factor) or FGF. FGF is prolific in PESE, as well as in the human placenta. On the 11th day of the incubation cycle of a chicken egg, the embryonic tissue shows a steep increase in the FGF, with the appropriate peptides to form the solid organs and bones (A1).

FGF is responsible for building the linings in the blood vessels, creating the infrastructure for the nutrients to flow to critical areas of the brain and organs. Research credits FGF with the potential to directly affect many neuro disorders because of clear results of the ability of FGF to affect the growth of neurites (A2). Neurites are signal senders (Axons) and signal receivers (dendrites) attached to the brain neurons.

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Research (A7) has also shown clearly that new cell cultures show a dramatic increase in peptide and amino acid uptake in the presence of FGF. This result gives credence to the hypothesis that embryonic growth is influenced by a very precise mechanism, which combines unique combinations of amino acids, peptides, and FGF.

Since FGF is not circulating in adults, multiple research projects on the effects of FGF serum to cure neurological disorders have been carried out. Fundamental to the research is the fact discovered by Altman, J. in 1962 (A26) that neural STEM cells are formed by the body in response to abnormalities, and are resident in certain zones of the brain. The brain is therefore ready to repair the damage, and these cells have shown to differentiate into a wide range of neurons (A27). Neurons derived from such neural stem cells are capable of migrating to various regions of the Central Nervous System. Over a decade of work, both in vivo and ex vivo has revealed that exposure to such neural stem cells to FGF permits direct differentiation into the required neural cells (A14, A25).

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Mechanism of Action
The role of FGF in human development

Source: PDR 2016

The bioactive peptides in Laminine stimulate the dormant stem cells to utilize the Phyto amino acids and marine protein to repair damaged aged cells.

Drying the photo-embryonic fluid before the peptides are “used up” to build organs and bones, allows us to provide this building, repairing, maintenance mechanism of perfectly balanced amino acids, peptides and growth factors to humans.

Nature has devised an extremely versatile mechanism to provide nutrition with miraculous precision to the embryo of living creatures. The precise blend of oligopeptides may be seen as building blocks, without a bridge, or a director. The role of such a director is fulfilled by a growth factor known as the Fibroblast Growth Factor, or FGF, also a bioactive peptide. FGF is prolific in proto-embryonic liquid as well as the human placenta. On the 11th day of the incubation cycle of a chicken egg, the chicken tissue shows a steep increase in these bioactive peptides, with the appropriate peptides to form the solid organs and bones (3). A detailed day-by-day study was performed in 1988 (5; 7). Discovered only in the seventies, FGF and bioactive peptides are critical in the development of embryos, including humans.

Bioactive peptides are responsible for building the linings in the blood vessels, creating the infrastructure for the nutrients to flow to critical areas of the brain and organs. Research credits bioactive peptides with the potential to directly affect many neuro disorders because of clear results of the ability of bioactive peptides to affect the growth of neurites (4). Neurites are signal senders (Axons) and signal receivers (dendrites) attached to the brain neurons.

Research (6) has also shown clearly that new cell cultures show a dramatic increase in peptide and amino acid uptake in the presence of FGF. This result gives credence to the hypothesis that embryonic growth is influenced by a very precise mechanism, which combines unique combinations of amino acids, peptides, and FGF.

References:

(1) Roberts, Pamela R, et al. Nutrition Vol. 14, No. 3, 1998
(2) Kuljis, Rodrigo O. Jour. of Neuropathology & Exp. Neur., 1994.
(3) Jiangyong Min, et al. Jour. of Neuroscience Res., 86:2984‐2991 (2008)
(4) Z.Y. Zhou, et al. Neuroscience, Vol. 90, No. 4, 1493‐1499, 1999
(5) Arvanitakis, Constantine. Am. Jour. of Physiology, Vol. 231, No. 1, July 1976.
(6) Kristoffer, ester S., ETC Research & Development, Oslo, Norway.
(A1) Joseph‐Silverstein, Jacquelyn, et al (June 1989) Basic Fibroblast Growth Factor in the Chick Embryo: Immunolocalization to Striated Muscle Cells and Their Precursors. The Journal of Cell Biology, 108: 2459‐2466.
(A2) Hatten, M. E., et al (1988) In Vitro Neurite Extension by Granule Neurons is Dependent upon Astroglial‐Derived Fibroblast Growth Factor. Developmental Biology, 125:280‐289.
(A4) Seed, Jennifer, et al (1988) Fibroblast Growth Factor Levels in the Whole Embryo and Limb Bud during Chick Development. Developmental Biology, 128:50‐57.
(A11) Seed, Jennifer, et al (1988) Fibroblast Growth Factor Levels in the Whole Embryo and Limb Bud during Chick Development. Developmental Biology, 128:50‐57.
(A14) La Spada, Albert R (December 2005) Huntington’s disease and Neurogenesis: FGF‐2 to the Rescue? Vol. 102.
(A24) Hagg, Theo (2005) Molecular Regulation of Adult CNS Neurogenesis: an Integrated View.
(A25) Bjugstad, K. B., et al (2001) IGF‐1 and bFGF Reduce Glutaric Acid and 3‐ Hydroxyglutaric Acid Toxicity in Striatal Cultures.
(A26) Altman, J. (1962) Science 132:1127‐1128.
(A27) Arlotta, P., et al (2003) Exp. Gerontol, 38:173‐182.


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8 COMMENTS

  1. Someone emailed me and said Laminine no longer produced its FGF from Avian egg whites. Apparently, a U.S. company produced a substitute and Laminine decided to use it.. This is supposed to have happened in 2012. Your website was dated 2014.
    Cab you shed some light about this for me?
    Larry Maheu June 30, 2015

    • Since early 2012, LifePharm Global Network has sourced its Fertilized Avian Egg Extract from organic, cage-free, hormone-free chicken farms in the United States, which is then developed with the process of Hygienic Evaporative Cooling. Hygienic Evaporative Cooling keeps the peptide chains that are so important in Laminine intact when converting the Fertilized Avian Egg Extract from a liquid to a powdered form. This technology is exclusive to LifePharm Global Network and was not readily available anywhere else in the world besides the United States. Previously, LPGN sourced its Fertilized Avian Egg Extract from Norway, but the change occurred in order to ensure the quality, traceability and supply of our materials. The laws governing avian products are especially stringent in the U.S.A., and LifePharm Global Network prides itself on operating under FDA and cGMP guidelines. You can find the answer to this, and other common questions here: http://altheadistributor.com/downloads_materials/ENG-Laminine-FAQ.pdf

  2. Hi there, I am a bodybuilder and FGF is listed as a banned substance for natural competitions. I have approached Lifepharm for clarification on the FGF content in Laminine and how long it stays in the body as clearly I cant risk having FGF in my urine if tested. However they have declined to assist me. Can you provide any guidance on this subject? How far out should I stop taking Laminine? Or indeed is it detectable? Thanks in advance. Jane

    • World Anti-Doping Agency prohibits any form of drug or chemical substance that will cause an athlete to have the edge, simply because he/she has access to these expensive aids for muscles gain in general. This can also refer to FGFs in vial, injectable form. This potent form of FGF is traceable and comes as a form of treatment to activate stem cells in the body. Laminine’s FGF form part of the egg peptides/protein/amino acids, it is food in form, much like how vitamins work. The FGF in Laminine is not synthesized and is naturally produced in a partially incubated egg. Thus Laminine should NOT be classified as one and the same with injectable FGF that anti-doping agency prohibits. To begin with, the potency is much different. On a personal note as to traceability, I believe it is difficult to quantify because you take Laminine as food, incorporated with your diet. Laminine can also be classified as as dietary supplements which is encouraged by USDAA, and not listed in the USAAD prohibited list.

    • Did you ever get a clearer answer to this question in terms of testing/potency? Going into weightlifting competitions next year, and have taken Laminine for almost 4 years, and I still see FGF on the prohibited substances list.

      • The FGF WADA is referring to is the injection form of FGF, those that are used for direct stem cell transplant. Laminine’s ingredient list does not specifically say FGF since it’s not there in its purest form. Rather, the FibroBlast GF (in lesser quantity as compared to FGF injection) is naturally found in the egg’s protein synthesis (The mine-days Fertilized Avian Egg Extract). In terms of potency, the injection will supersede the food supplement. Laminine works for general cellular repair because of its combination with other ingredients.

  3. To say that the human body does not produce FGF is incorrect – the body produces 22 types of FGF. Which raises another issue: when you state that laminine contains FGF, which FGF are you referencing? As mentioned previously, humans produce 22 different FGF peptides that are produced by different tissues, signal through different receptors and exert different effects on different cell types.

    • Referring to the 22 members of the FGF family that have been identified, although these are structurally related to signaling molecules (amino acids found in the body), the best source will still be through diet/food because the body (adults) can no longer make a significant amount of these, as compared to fetus or infants, where FGF/angiogenesis is required.

      Laminine’s FGF2 (family of growth factors) has been found in other animals such as cows, and in the case of Laminine, extracted from partially incubated hen egg, that has the highest quality of FGF known to science to date. Although the basic fibroblast growth factor (FGF-2) in the hypothalamic-pituitary system can be found, the expression of FGF-2 mRNA in the pituitary is low; the protein is widely distributed in both its neural and anterior lobes. Thus when the egg extract (Laminine) was discovered (also known as YTE), the supply through a diet of these proteins (rich in FGF2), has to come through a supplement. We know this based on clinical studies that show the ingestion of supplement rich with FGF(2), has greatly affected cells to heal more rapidly, than a person just eating healthy food.

      We do take note of rephrasing the article if it insinuated that the body cannot produce FGFs altogether. Thank you.

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