The FGF2 Improves VEP (Visual evoked potential) in Dyslexic Children
Laminine is known to work on several health issues, ranging from cancer suppression, kidney disease, wound healing, muscle development, and nerve problems. While we have yet to publish a study in dyslexia, the FibroBlast Factor (FGF2) in Laminine already has studies that may help improve children with this problem, specially if supplemented before age 25, or before the brain fully develops.
VEP or Visual Evoked Potential or simply an evoked response is an electrical potential recorded from the nervous system of a human or other animal following presentation of a stimulus. Although the amplitudes tend to be low, ranging from less than a microvolt to several microvolts, the signal from this test can be recorded from cerebral cortex, brain stem, spinal cord and peripheral nerves. (Source Wikipedia)
Recent Advances in Human Neurophysiology [A]
A study in March 1998, Japan reported the effect of FGF-2 therapy in children with dyslexia. Participants included both sexes between 8 and 12 years of age, in two groups, totaling 41 respondents.
The stimulation was performed using a white stroboscopic xenon flash (Grass PS22). All stimuli were presented binocularly with a variable repetition rate during awake state, 16 electrodes were placed according to 10-20 international system, amplifier bandpass was 1-35 Hz, 200 epochs were averaged and obtained twice. Symmetry analysis of each area was performed using Pearson coefficient (PC) to know the linear correlation and energy ratio (ER) to know the symmetry in energy (comparison of the area below the curve of one region respect to contra lateral), for 50-200 and 200-400 milliseconds (ms) segments, the result of each area in a specific segment of time of every dyslexic child was compared with a control group (n=25, age matched) using Z transform (p<0.025) in order to know the significant deviations.
FGF2 (in vial form, not Laminine) was administered at dosage of 0.2 mg/kg of body weight every 2 weeks during 12 months to TG, the UG received only neurophsycological therapy.
The VEPs showed in the initial study that the PC was significantly (p<0.025) reduced in 58 % of dyslexic respect to normal controls in at least one segment and the 48 % in the 200-400 ms segment. In ER 48% of patients showed asymmetries at least in one segment, a great reduction of voltage and area of N100 component on left occipital and temporal regions was observed in 28 % of dyslexic children (Fig. 1 a and 2 a ), causing the mentioned asymmetries in ER and PC, in occipital regions only the 26 % showed asymmetries. After 12 months of treatment with FGF2, a significant (p<0.01) improvement in PC was observed in T5-T6 (Fig. 3) in 200-400 ms segment, the ER improved significantly (p<0.01) in both segments of T5-T6 (Fig. 3 ),. The UG did not show significant changes.
The improvement in ER was associated with the increase of voltage (area below the curve) on the regions in which previously was reduced ( Fig. 1 b and 2 b), this occurs more frequently on left occipital and temporal regions. This correlates with neurophsycological studies in which several authors demonstrate anatomical deficits on these regions of dyslexic children (Greenblat, 1973, Ajax et al.1977, Staller et al. 1978).
The above mentioned suggests an increase on the number of the responding neurons of these regions, probably due to new pathways formation between geniculate lateral nucleus and area IV of occipital cortex as well as between occipital and temporal cortex, there was also an increase in the activity of neurons of the mentioned areas. The VEPs improvement in PC suggest a better synchrony and organisation.
We conclude that the flash VEPs are useful for detecting the neurophysiological abnormalities in dyslexic patients and for monitoring the effects of treatments like the one with FGF2, in which a significant improvement of dyslexic children was observed in neuropsychological and neurophysiological parameters.
Fibroblast Growth Factor (FGF) Improves Children with Language Disabilities. [B]
Previous studies of this group have also shown that the IM administration of FGF improves children with mental retardation. They report the changes in children with brain damage and language disabilities treated with FGF. Two groups, controls (n=10) and treated (n=48), were subdivided in two subgroups: comprehension and expression deficits. The treatment consisted in the IM administration of FGF (0.7 ug/kg) every 2 weeks during 6 months.
Distances in the semantic network as well as phonologic were quantified in all patients. The results showed that FGF treated children from the comprehension subgroup had a reduction in the semantic distances of 20%, whereas their control group increased those distances in 49%. The expression FGF treated subgroup showed a decrease of 60% in phonologic distances, whereas in children from the control group they decreased in only 38%. These results show that FGF helps in reducing language disabilities caused by brain damage.
[A]L. C. Aguilar, P. Rosique, F. Alfaro, R. Martín, S. Cruz, A. Islas, and J. M. Cantú., March 1998. Okazaki, Japan.
[B] 9th World Congress of the International Association for the Scientific Study of Mental Deficiency. 5 – 9 August 1992; Queensland, Australia.