Updated January 18, 2017
LifePharm Research (parent company) is constantly in product research and innovation. Using Laminine as the base formula, the company introduces LifePharm OMEGA+++. Combined with Laminine (Fertilized Avian Egg Extract), Laminine OMEGA+++ targets these symptoms by focusing on the epicenter of our bodies -the area whose strength is essential for us to feel and look healthy. It improves our heart’s circulatory system. You can take Laminine Omega+++ 1-2 capsules per day, ideally 30 minutes before your first meal of the day.
LifePharm’s Laminine OMEGA+++ is unique in its use of only the highest quality sources for Omega Fatty Acids 3 (EPA and DHA), 6, 9, CoQ10 Extended Release, Vitamin K2, along with an added boost of the
Fertilized Avian Egg Extract, and combines them into one supplement.
● Heart discomfort
● Chest discomfort
● Occasional coughing or wheezing
● Lack of appetite and/or queasiness
● Slow recovery following exercise or other activity
● Certain inflammation
Watch Laminine Omega Plus video and how it can help your heart and bones, and provide 24-hour antioxidant
Laminine OMEGA+++ is a potent supplement that targets your heart circulation, also an anti-oxidant, anti-inflammatory, & directs calcium to bones & teeth instead of calcifying elsewhere. There are 3 important ingredients added.
Laminine (Original) is the best Omega partner for homeostasis. It promotes faster cell repair, restoration,or rejuvenation. Laminine OMEGA+++ does not contain all the 22 amino acids that Laminine (Original) has. Laminine (Original) is more potent when it comes to FGF extract.
People who are 40 years old and above are best suited with the following dosage:
→ 1 Laminine Omega in the morning (with meal)
→ 1-2 Laminine (Original) early evening (before or after meal)
If you experience heart or chest discomfort, occasional coughing or wheezing, tires easily – Laminine OMEGA+++ is for you. With these symptoms, you may have the beginnings or onset of heart circulatory problems. It can only get worse as we age and depending on your genetic make-up, eating habit and activities. Laminine OMEGA+++ also help address loss of appetite and queasiness. Best of all, Laminine Omega+++ combined with both Laminine and other ingredients that helps the heart – you can experience quicker recovery after an exercise or physical activity.
Laminine Omega +++ is a super combination of the highest quality ingredients:
1. Omega Fatty Acids 3, 6, 9
2. EPA and DHA
4. Vitamin K2,
5. Fertilized Avian Egg Extract.
Help maintain normal levels of HDL (“good” cholesterol) and LDL (“bad” cholesterol), which keeps excess cholesterol from building and triggers the brain to send proper signals to the circulatory system.
A powerful antioxidant that helps fight oxidative stress in the blood vessels, leaving them clear for proper blood flow. ER stands for Extended Release, which means you can be protected up to 24 hours from free radicals.
It helps to direct calcium to the bones and teeth, where it belongs, keeping the calcium from attaching itself to the arteries.
It stimulates stem cells, allowing each of the other ingredients in Laminine OMEGA+++ to perform their function effectively.
The primary role of Laminine OMEGA+++ clears the body’s internal pathways to optimize circulatory health.
• Optimal blood flow to the brain and other organs
• Better cognitive function
• Increased energy
• Better sleep
• Reduced fatigue
• Increased immune response
• Lower stress and cortisol levels
• Improved signaling throughout the body
• More pliable arteries and blood vessels
• Increased agility
• Faster recovery time following intense exercise
• Controlled release and long-term effect
• Balanced triglyceride levels
Coenzyme Q10 (CoQ10) is a substance that’s found naturally in the body and helps convert food into energy. CoQ10 is found in almost every cell in the body, and it is a powerful antioxidant.
Antioxidants fight damaging particles in the body known as free radicals, which damage cell membranes, tamper with DNA, and even cause cell death. Scientists believe free radicals contribute to the aging process, as well as a number of health problems, including heart disease and cancer.
Antioxidants, such as CoQ10, can neutralize free radicals and may reduce or even help prevent some of the damage they cause. Some researchers believe that CoQ10 may help with heart-related conditions, because it can improve energy production in cells, prevent blood clot formation, and act as an antioxidant.
General use of this ingredient: Some studies suggest that coenzyme Q10 supplements, either by themselves or with other drug therapies whether oral or intravenous in higher* dosage, may help prevent or treat the following conditions:
* Ask a health professional on CoQ10 supplementation on higher dosing.
One clinical study found that people who took daily CoQ10 supplements within 3 days of a heart attack were less likely to have subsequent heart attacks and chest pain. They were also less likely to die of heart disease than those who did not take the supplements. Anyone who has had a heart attack should talk with their health care provider before taking any herbs or supplements, including CoQ10.
There’s evidence that CoQ10 may help treat heart failure when combined with conventional medications. People who have congestive heart failure, where the heart isn’t able to pump blood as well as it should may also have low levels of CoQ10. Heart failure can cause blood to pool in parts of the body, such as the lungs and legs. It can also cause shortness of breath.
Several clinical studies suggests that CoQ10 supplements help reduce swelling in the legs; reduce fluid in the lungs, making breathing easier; and increase exercise capacity in people with heart failure. But not all studies are positive — some find no effect — so using CoQ10 for heart failure remains controversial. CoQ10 should never be used by itself to treat heart failure, and you should ask your health care provider before taking it for this condition.
Several clinical studies involving small numbers of people suggest that CoQ10 may lower blood pressure. However, it may take 4 – 12 weeks to see any change. In one analysis, after reviewing 12 clinical studies, researchers concluded that CoQ10 has the potential to lower systolic blood pressure by up to 17 mm Hg and diastolic blood pressure by 10 mm Hg, without significant side effects. More research with greater numbers of people is needed. Don’t try to treat high blood pressure by yourself — see your health care provider for treatment.
People with high cholesterol tend to have lower levels of CoQ10, so CoQ10 has been proposed as a treatment for high cholesterol, but so far there’s no evidence whether it works or not. There is some evidence it may reduce side effects from conventional treatment with cholesterol-lowering drugs called statins, which reduce natural levels of CoQ10 in the body. Taking CoQ10 supplements can bring levels back to normal. Plus, studies show that CoQ10 may decrease the muscle pain associated with statin treatment. Ask your health care provider if you are interested in taking CoQ10 with statins.
CoQ10 supplements may improve heart health and blood sugar and help manage high blood pressure in people with diabetes. Two studies found that 100 mg of CoQ10 twice daily improved A1c levels, a measure of long-term blood sugar control. But another study found no effect. If you have diabetes, talk to your doctor or registered dietitian before using CoQ10.
Several clinical studies suggest that CoQ10 may help prevent heart damage caused by certain chemotherapy drugs, adriamycin, or other athracycline medications. More studies are needed, however. Talk to your health care provider before taking any herbs or supplements if you are undergoing chemotherapy.
Clinical research indicates that introducing CoQ10 prior to heart surgery, including bypass surgery and heart transplantation, can reduce damage caused by free radicals, strengthen heart function, and lower the incidence of irregular heart beat (arrhythmias) during the recovery phase. You shouldn’t take any supplements before surgery unless your health care provider approves.
Gum disease is a common problem that causes swelling, bleeding, pain, and redness of the gums. Clinical studies show that people with gum disease tend to have low levels of CoQ10 in their gums. A few studies with small numbers of people found that CoQ10 supplements led to faster healing and tissue repair, but the studies were not well designed. More research is needed.
Millions of people take calcium supplements to maintain healthy bone. Yet few patients or physicians realize that optimizing bone integrity involves more than taking a single mineral supplement. A critical additional component for bone and cardiovascular health is vitamin K2.
Recent research has revealed that, without vitamin K2, calcium regulation is disrupted. In fact, low levels of vitamin K2 are associated with an increased risk of heart disease and atherosclerosis.1 Astute doctors have long known that people with a lack of calcium in their bones are more likely to possess an excess of calcium in their arteries, and vice versa.
The resulting lack of calcium in bone leads to osteoporosis, while the deposition of calcium in the arterial wall leads to coronary heart disease and other manifestations of cardiovascular, renal, and neurodegenerative disease.
Although vitamin K has been around for decades, dietary recommendations have been overshadowed by the nominal amount required for healthy blood clotting—and have ignored the optimal amounts of vitamin K needed to maintain healthy bones and arteries. In this article, we’ll explore how vitamin K2 regulates calcium as well as the recent evidence supporting this unique vitamin in preventing heart disease and osteoporosis as well as certain types of cancer.
Osteoporosis and heart disease—they seem as unconnected as two conditions can possibly be. On the surface, they do share a few common features. Both conditions develop with age. It’s rare for someone to have either condition at age 30, but both are common in the sixth or seventh decade of life. Both conditions don’t develop overnight, but require many years to emerge.
Just as osteoporosis requires decades to develop, coronary atherosclerosis also accumulates bit by bit over decades, starting in a person’s 20s (or earlier) and building gradually until a heart attack or other catastrophe occurs.
But the resemblance appears to stop there—that is, until we dig beneath the surface. As long ago as the 19th century, scientists knew that an unknown material lining diseased arteries resembled a bone-like structure. For the next 100 years, however, this finding was dismissed as a curiosity, an inevitable accompaniment of aging, and evidence of “wear and tear,” just like arthritis.
Dr. Linda Demer and her team at the University of California, Los Angeles, were among the first to unravel this curious connection by successfully identifying a protein in human atherosclerotic tissue, which was previously believed to reside only in bone tissue. This protein, called bone morphogenetic protein-2, plays an important role in bone formation. Since then, several other key regulators of bone formation have been identified in atherosclerotic plaque tissue, such as matrix GLA-protein and osteopontin, suggesting that common factors might influence both arterial and bone health.3
Another curious observation increased the momentum to find a link between bone and arterial diseases. People who had osteoporosis, or a lack of calcium in their bones, were more likely to possess an excess of calcium (bone) in arteries and vice versa. In fact, what had often been simply assumed to be calcium deposits or calcified plaque was actually fully formed bone tissue. Vascular calcification should therefore be more properly designated as vascular ossification—bone formation within blood vessels.
Likewise, many “risk factors” for coronary atherosclerosis were also prevalent in osteoporosis: aging, diabetes, sedentary lifestyle, smoking, and high cholesterol. Scientists questioned why there was such a tight link between excess calcium in one organ (bones) and deficient calcium in another (arteries). And why, in some apparently healthy people, are the two present simultaneously to such extremes?
Initially, some proposed that there may be an abnormal transfer of calcium from bones to arteries. This did not hold up to scrutiny, however, since each system proved to be under its own regulation.
Although certain prescription drugs, such as raloxifene (Evista®) and alendronate (Fosamax®), addressed the problem of osteoporosis, no solution emerged to address both bone and arterial health, that is, until now. Current research is highlighting the importance of nutritional solutions to control the link between arterial and bone diseases by addressing calcium metabolism in the body—in particular, the role played by vitamin K2.
In nature, vitamin K is found in two forms: vitamin K1 (phylloquinone) in leafy, green vegetables, and vitamin K2 (menaquinone) in organ meats, egg yolks, and dairy products.
Vitamin K is required by the human liver to manufacture blood-clotting proteins (factors II, VII, IX, X; and proteins S and C). This is the basis for administering the vitamin K-blocking drug, warfarin (Coumadin®) to people who have blood clots or are at risk for blood clot formation, since clot formation is effectively suppressed by the drug.
Determination of the human need for vitamin K was therefore based on the amount necessary to maintain a normal balance between blood clotting and thinning. Blood shouldn’t be excessively “thinned” and prone to abnormal bleeding, nor excessively “thick” and prone to clotting in the wrong place.
Beyond its role in blood clotting, recent research has revealed that vitamin K also plays a vital role in maintaining healthy bones and arteries by keeping calcium in the bones and out of the arteries.
Unfortunately, the recommended dietary intake of vitamin K required for blood clot regulation is much lower than that required for optimal bone and arterial health.
Since it was first discovered in 1929, vitamin K has best been known for its crucial role in the blood-clotting process. Since that time, scientists have uncovered compelling evidence that vitamin K plays an equally important role in bone health.
The majority of vitamin K research to date has focused on vitamin K1, the dominant dietary form of vitamin K that occurs in green, leafy vegetables. Yet it appears that vitamin K2, which occurs in organ meats, egg yolks, and dairy products, is a more important inducer of bone mineralization in human osteoblasts (bone-building cells) than vitamin K1.
The Japanese long ago recognized the power of vitamin K2 to maintain or restore bone health. In certain regions of Japan, a staple dish called natto or fermented soybean, frequently eaten several times a week, is uniquely rich in vitamin K2. Recent scientific examination has pinpointed vitamin K2, and in particular vitamin K2 as menaquinone-7 (MK-7), as the active ingredient in this popular eastern Japanese dish, as having a supportive effect on bone quality during osteoporosis treatment.
People living in the Japanese regions where this dish is eaten have several-fold greater blood levels of vitamin K2 (MK-7), accompanied by less osteoporosis and bone fractures.
These findings are supported by clinical trials, in which vitamin K2 has been shown to successfully reduce the incidence of bone fractures. A two-year Japanese study found that vitamin K2 (MK-4) reduced the incidence of vertebral (spine) fractures by 52% in 120 patients with osteoporosis, compared with patients who did not receive this nutrient.
The high dose used in this trial—as with most studies examining vitamin K2’s effect on bone density—was 45 mg/day, a prescription dose used in Japan to treat osteoporosis that is unavailable in the US. As you will read later, lower doses of K2 found in dietary supplements appear to also provide significant benefits.
Fit and trim at age 67, Walter had no reason to believe that he had any hidden health conditions. He’d had annual physicals for the past seven years, passing them all. According to his doctor, his cholesterol numbers had been fine for years.
However, Walter’s brother-in-law, a physician whose own brush with heart disease prompted him to warn everyone else in the family about the possibility, suggested that he undergo a computed tomography heart scan.
Walter’s heart scan score was 3,367, a high score that signaled a dangerous content of calcified atherosclerotic plaque in his coronary arteries linked to a high risk for heart attack. In fact, Walter’s score put him in the 99th percentile, meaning that his calcium score was in the worst 1% of all men in his age group (and carried an annual risk for heart attack of 25% without preventive efforts).
At about the same time, Walter enrolled for a screening service that came to his church offering ultrasound screening for abdominal aneurysm, carotid disease, and osteoporosis. While Walter proved to have no aneurysm or carotid issues, he did show the bone density of someone 20 years older, revealing an advanced state of osteoporosis.
While seemingly unrelated, Walter’s arterial calcification and osteoporosis were likely connected through the common mechanism of inadequate levels of vitamin K.
Vitamin K2 has also proven to be as effective as prescription drugs in reducing the incidence of bone fractures. In one Japanese study in post-menopausal women that compared the effect of K2 (MK-4) with the drug Etidronate (Didronel®) on the incidence of vertebral (spine) fracture, women taking K2 at a dose of 45 mg per day experienced a fracture rate of 8.0% compared with 8.7% for those taking the drug therapy. Furthermore, women taking both MK-4 and the drug experienced a 3.8% fracture rate—a dramatic combined effect. In comparison, in a placebo group who received neither K2 nor drug therapy, nearly 21% of women experienced bone fractures.8
Experimental animal models of osteoporosis have also revealed that MK-4 improves bone architecture, increases bone mass and mechanical strength, stimulates mineralization (deposition of calcium), and enhances collagen architecture—a cross-linking of fibrous tissue that yields tough but supple bone that is more resistant to fracture.
On the other hand, osteoporosis—the excessive loss of bone mineral density—results in fractures and leads to devastating events common in those over 65 years, even with minor injuries like a fall. Unfortunately, the drug industry focuses on prescribing drugs late in life when the risk for fracture is high. Strategies that involve nutritional supplements are different.
Firstly, they lack the high cost and side effects of prescription drugs. Secondly, they can potentially be started at an earlier age and taken over 20, 30, or more years in order to yield possibly greater benefit than drug therapy started at the age of 60 to bail out a process that has developed over decades. Although there are no clinical trials for such an extended period, this is an area worthy of future investigation.
While calcium is essential for good health, aberrant calcium metabolism can lead to disorders such as osteoporosis and cardio-vascular disease. Vitamin K2 is emerging as a key factor in regulating calcium in the body.
Insufficient vitamin K2 leads to decreased bone mineral density, a key factor in osteoporosis, and an excess of calcium in the arterial wall, which increases the risk of heart disease.
In Japan, vitamin K2 has been shown to substantially improve osteoporosis when given either as a high-dose prescription agent or in the staple Japanese dish called natto, which is particularly rich in K2.
Studies have also shown that even modest amounts of vitamin K2 fight heart disease by controlling calcium-regulating proteins in vascular tissue, which keeps calcium out of the arteries and prevents the formation of dangerous calcified plaques.
Vitamin K2 occurs in much smaller quantities in the diet than vitamin K1. Most of us, therefore, get little of these K2-rich foods.
Current dietary guidelines for vitamin K focus on how much is needed to regulate blood clotting and have largely ignored the much higher amount needed to maintain healthy bones and arteries.
Cumulative Incidence of Hepatocellular
Carcinoma Diagnosed in Women Treated with Vitamin K2
Normal deposition of calcium occurs in two organs: bone and teeth. Abnormal deposition of calcium in the body occurs in three places: the inner lining of the arteries (the intima) where atherosclerotic plaque accrues; the muscle layer of arteries (“medial calcification”); and heart valves. Vitamin K2 appears to be the form of vitamin K that contributes to controlling all of these phenomena.
However, calcium has historically been viewed as a passive marker, certainly not an active participant in heart disease. Some maintained that calcium was nothing more than a remnant of prior “rupture,” a scar from dangerous inflammatory activity of soft plaque. They even argued that calcium was, in fact, a reflection of increased plaque stability, as the “hard” material was not itself prone to rupture. Thus, they believed that calcium played no active role in contributing to atherosclerotic plaque.
Those arguments have now been dashed by new observations. A definitive connection between vitamin K2 levels and heart disease, in terms of a large-scale, well-controlled clinical trial, was first described in 2004 in the Rotterdam Heart Study—a Dutch trial that tracked 4,800 participants for seven years.
The study revealed that participants who ingested the greatest quantities of vitamin K2 in their diet experienced a 57% reduction in death from heart disease than people who ingested the least. The same relationship did not hold for vitamin K1. Unfortunately, in this study MK-4 and MK-7 intake and levels were not separately analyzed but were grouped together, along with other MK categories such as MK-8 and MK-9.
Higher intakes of vitamin K2 also corresponded to less calcium deposition in the aorta (an indirect measure of atherosclerosis), whereas participants who ingested less K2 were more likely to show moderate or severe calcification. The lowest risk of heart attack and aortic calcification was seen in participants who included more than 32.7 mcg a day of vitamin K2 in their diet.1
The size and quality of the Rotterdam Heart Study gave credibility to the powerful association between vitamin K2 dietary intake and heart disease and suggests that vitamin K2 may confer cardiovascular benefits by inhibiting arterial calcification.
Physicians and scientists are now intensely interested in monitoring and halting the accumulation of coronary calcium, since they know that it comprises a significant portion of atherosclerotic plaque volume.
It appears therefore that the accumulation of calcium signals actively growing atherosclerotic plaque and that vitamin K deficiency may set the stage for this pathogenic process.
The menaquinones make up about 10% of vitamin K consumption and can also be synthesized in the gut by healthy microflora. There are several different forms of menaquinone. Menaquinones are short-listed using the notation MK-n, where the ‘n’ specifies the number of prenyl side chains.
MK-4 is available in high doses by prescription. MK-8 and MK-9 are found in fermented food products like cheese. Soy natto is a rich source of the highly bioavailable form of K2 known as MK-7. MK-4, also known as menatetrenone, is distinct from other menaquinones because it is not a major constituent of MK-n produced by gut microflora.
Exciting preliminary evidence is emerging that vitamin K2 may suppress cancer.
In a serendipitous study, initially conducted to explore whether vitamin K2 provided protection against bone loss, investigators noticed that this nutrient dramatically reduced the risk of liver cancer.
In this small Japanese study of 40 women who had liver cirrhosis from viral infections, there was a marked difference in the incidence of liver cancer, with only 2 of 21 developing cancer in the MK-4 group compared with 9 of 19 in a control group.15 The chart on this page shows the significant protective effect against primary liver cancer conferred by vitamin K2 in this study.
Similarly, a pilot study in 61 people recovering from surgical removal of hepatocellular carcinoma (liver cancer) showed that 45 mg/day of MK-4 (the dose used in Japan to treat osteoporosis) enhanced cancer-free survival by a wide margin.
In the laboratory, vitamin K2 demonstrates inhibitory effects against myeloma and lymphoma, suggesting possible applications for individuals fighting these hematologic cancers.
Perhaps this is just the tip of the iceberg with vitamin K2’s fascinating effects on cancer. As most of the observations are just getting underway and some have arisen by chance observations, this is an area worth watching. Perhaps even more exciting for our purposes is discovering whether vitamin K2 prevents cancer if taken over a long period.
Vitamin K1 occurs naturally in green leafy vegetables, whereas vitamin K2 is found in relatively few foods. Organ meats, egg yolks, and the Japanese condiment natto, are sources of vitamin K2, of which natto is by far the richest source. Unfortunately, natto is an acquired taste and a dish that the average American may be unwilling to try. Vitamin K2 is also found in modest quantities in traditionally fermented cheeses, in particular, Swiss Emmental and Norwegian Jarlsberg.18 Of total vitamin K dietary intake, only about 10% is the K2 form.
Vitamin K deficiency can also result from impaired absorption, in addition to not getting enough in the diet. It can also be caused by prolonged use of anti-biotics, since bacteria that normally reside in the colon (and are obliterated by antibiotic use) are responsible for producing approximately half of the vitamin K needed every day. Unfortunately, the present recommended dietary intake of vitamin K, 90 mcg/day for women and 120 mcg/day for men, may be inadequate to maintain optimal heart and bone health.
Although vitamin K1 is rapidly cleared from the blood, K2 lingers in the blood for an extended period when taken orally and can rise to much greater levels than seen with K1. Vitamin K2 appears to be safe, with no side effects identified even at high doses. In Japan, K2 substantially improves bone density and prevents osteoporotic fractures, given either as a high-dose prescription agent (45 mg/day) or in the Japanese dish natto. Together, these findings suggest that vitamin K2 may be the preferred form of vitamin K for supplemental use.
What dose of vitamin K2 is best? Scientists are still debating this question. Supplements generally contain between 50 mcg and 1,000 mcg of vitamin K2. Even the low end of the supplement dose of 50 mcg a day may help to support healthy bone density and protect the arterial wall from calcification. Life Extension has long recommended about 1,000 mcg a day of vitamin K2, along with 9,000 mcg vitamin K1 for most people.
The possible role of vitamin K2 in preventing coronary plaque development has emerged from observations of its effects on several bone proteins, whose main function is to keep calcium where it belongs in the body.
Osteocalcin is a calcium-regulating protein that is controlled by vitamin K2. When vitamin K is present, osteocalcin normally undergoes a process called carboxylation, which binds osteocalcin to the mineral portion of bone. However, in vitamin K2 deficiency, osteocalcin cannot perform this function, resulting in unrestrained calcium resorption (removal) from bone tissue that leads to osteoporosis.
The opposite situation seems to occur in the arteries. Calcium is deposited because another protein called matrix GLA-protein, which is a calcification inhibitor and is also K2-controlled, cannot undergo the process of carboxylation in a vitamin K-deficient state. Because only carboxylated matrix GLA-protein inhibits calcification, undercarboxylated matrix GLA-protein has been found to occur in unusually high concentration at the edge of calcified and atherosclerotic plaques, suggesting it plays an active role in depositing calcium in plaque.4 Impairment of the function of osteocalcin and matrix GLA-protein due to incomplete carboxylation results in an increased risk for developing osteoporosis and vascular calcification, respectively.
Omega-3 fatty acids are considered essential fatty acids. They are necessary for human health but the body can’t make them, you have to get them through food. Omega-3 fatty acids in Laminine OMEGA+++, can be found in fish, such as salmon, tuna, and halibut, other seafood including algae and krill, some plants, and nut oils. Also known as polyunsaturated fatty acids (PUFAs), omega-3 fatty acids play a crucial role in brain function, as well as normal growth and development.
They have also become popular because they may reduce the risk of heart disease. The American Heart Association recommends eating fish (particularly fatty fish such as mackerel, lake trout, herring, sardines, albacore tuna, and salmon) at least 2 times a week.
Research shows that omega-3 fatty acids reduce inflammation and may help lower risk of chronic diseases such as heart disease, cancer, and arthritis. Omega-3 fatty acids are highly concentrated in the brain and appear to be important for cognitive (brain memory and performance) and behavioral function. In fact, infants who do not get enough omega-3 fatty acids from their mothers during pregnancy are at risk for developing vision and nerve problems.
Frequently ignored are the symptoms of omega-3 fatty acid deficiency that include fatigue, poor memory, dry skin, heart problems, mood swings or depression, and poor circulation. Instead, these are attributed to other factors.
It is important to have the proper ratio of omega-3 and omega-6 (another essential fatty acid) in the diet. Omega-3 fatty acids help reduce inflammation, and most omega-6 fatty acids tend to promote inflammation. The typical American diet tends to contain 14 – 25 times more omega-6 fatty acids than omega-3 fatty acids, which many nutritionally oriented physicians consider to be way too high on the omega-6 side.
The Mediterranean diet, on the other hand, has a healthier balance between omega-3 and omega-6 fatty acids. Many studies have shown that people who follow this diet are less likely to develop heart disease. The Mediterranean diet emphasizes foods rich in omega-3 fatty acids, including whole grains, fresh fruits and vegetables, fish, olive oil, garlic, as well as moderate wine consumption.
People who follow a Mediterranean style diet tend to have higher HDL or “good” cholesterol levels, which help promote heart health. Inuit Eskimos, who get high amounts of omega-3 fatty acids from eating fatty fish, also tend to have increased HDL cholesterol and decreased triglycerides (fats in the blood). Several studies have shown that fish oil supplements reduce triglyceride levels. Finally, walnuts (which are rich in alpha linolenic acid or ANA, which converts to omega-3s in the body) have been reported to lower total cholesterol and triglycerides in people with high cholesterol levels.
Several clinical studies suggest that diets rich in omega-3 fatty acids lower blood pressure in people with hypertension. An analysis of 17 clinical studies using fish oil supplements found that taking 3 or more grams of fish oil daily may reduce blood pressure in people with untreated hypertension. Doses this high, however, should only be taken under the direction of a physician.
The role of omega-3 fatty acids in cardiovascular disease is well established. One of the best ways to help prevent heart disease is to eat a diet low in saturated fat and to eat foods that are rich in monounsaturated and polyunsaturated fats (including omega-3 fatty acids).
Clinical evidence suggests that EPA and DHA (eicosapentaenoic acid and docosahexaenoic acid, the 2 omega-3 fatty acids found in fish oil) help reduce risk factors for heart disease, including high cholesterol and high blood pressure.
Fish oil has been shown to lower levels of triglyceride (fats in the blood), and to lower the risk of death, heart attack, stroke, and abnormal heart rhythms in people who have already had a heart attack. Fish oil also appears to help prevent and treat atherosclerosis (hardening of the arteries) by slowing the development of plaque and blood clots, which can clog arteries.
Large population studies suggest that getting omega-3 fatty acids in the diet, primarily from fish, helps protect against stroke caused by plaque buildup and blood clots in the arteries that lead to the brain. Eating at least 2 servings of fish per week can reduce the risk of stroke by as much as 50%.
However, high doses of fish oil and omega-3 fatty acids may increase the risk of bleeding. People who eat more than 3 grams of omega-3 fatty acids per day (equivalent to 3 servings of fish per day) may have higher risk for hemorrhagic stroke, a potentially fatal type of stroke in which an artery in the brain leaks or ruptures.
People with diabetes often have high triglyceride and low HDL levels. Omega-3 fatty acids from fish oil can help lower triglyceride and apoproteins (markers of diabetes), and raise HDL, so eating foods or taking fish oil supplements may help people with diabetes.
Another type of omega-3 fatty acid, ALA (from flaxseed, for example) may not have the same benefit as fish oil. Some people with diabetes can’t efficiently convert ANA to a form of omega-3 fatty acids that the body can use. Also, some people with type 2 diabetes may have slight increases in fasting blood sugar when taking fish oil, so talk to your doctor to see if fish oil is right for you.
Most clinical studies examining omega-3 fatty acid supplements for arthritis have focused on rheumatoid arthritis (RA), an autoimmune disease that causes inflammation in the joints. A number of small studies have found that fish oil helps reduce symptoms of RA, including joint pain and morning stiffness.
One study suggests that people with RA who take fish oil may be able to lower their dose of non-steroidal anti-inflammatory drugs (NSAIDs). Contrary to prescription medications, fish oil does not appear to slow progression of RA, only to treat the symptoms. Joint damage still occurs.
Laboratory studies suggest that diets rich in omega-3 fatty acids (and low in the inflammatory omega-6 fatty acids) may help people with osteoarthritis, although more study is needed. New Zealand green lipped mussel (Perna canaliculus), another potential source of omega-3 fatty acids, has been reported to reduce joint stiffness and pain, increase grip strength, and moreso improve walking pace in a small group of people with osteoarthritis. For some people, symptoms got worse before they improved.
Controlled clinical trials
An analysis of 17 randomized, controlled clinical trials looked at the pain relieving effects of omega-3 fatty acid supplements in people with RA or joint pain caused by inflammatory bowel disease (IBS) and painful menstruation (Dysmenorrhea). The results suggest that omega-3 fatty acids, along with conventional therapies such as NSAIDs, may help relieve joint pain associated with these conditions. These studies were not conducted for Laminine Omega, but for a generic fatty acid ingredient.
Systemic lupus erythematosus (SLE)
Several small studies suggest that EPA and fish oil may help reduce symptoms of lupus, an autoimmune condition characterized by fatigue and joint pain. However, 2 small studies found fish oil had no effect on lupus nephritis (kidney disease caused by lupus, a frequent complication of the disease).
Some studies suggest that omega-3 fatty acids may help increase levels of calcium in the body and improve bone strength, although not all results were positive. Some studies also suggest that people who don’t get enough of some essential fatty acids (particularly EPA and gamma-linolenic acid [GLA], an omega-6 fatty acid) are more likely to have bone loss than those with normal levels of these fatty acids. In a study of women over 65 with osteoporosis, those who took EPA and GLA supplements had less bone loss over 3 years than those who took placebo. Many of these women also experienced an increase in bone density.
Studies have found mixed results as to whether taking omega-3 fatty acids can help depression symptoms. Several studies have found that people who took omega-3 fatty acids in addition to prescription antidepressants had a greater improvement in symptoms than those who took antidepressants alone.
Other studies show that omega-3 fatty acid intake helps protect against postpartum depression, among other benefits. However, other studies have found no benefit. Studies are also mixed on whether omega-3 fatty acids alone have any effect on depression. Depression is a serious illness and you should not try to treat it on your own. See a doctor for help.
In a clinical study of 30 people with bipolar disorder, those who took fish oil in addition to standard prescription treatments for bipolar disorder for 4 months experienced fewer mood swings and relapse than those who received placebo. But another 4 month long clinical study treating people with bipolar depression and rapid cycling bipolar disorder did not find that EPA helped reduce symptoms.
Preliminary clinical evidence suggests that people with schizophrenia may have an improvement in symptoms when given omega-3 fatty acids. However, a recent well designed study concluded that EPA supplements are no better than placebo in improving symptoms of this condition.
Children with attention deficit/hyperactivity disorder (ADHD) may have low levels of certain essential fatty acids (including EPA and DHA). In a clinical study of nearly 100 boys, those with lower levels of omega-3 fatty acids had more learning and behavioral problems (such as temper tantrums and sleep disturbances) than boys with normal omega-3 fatty acid levels.
Ultimately, studies examining whether omega-3 fatty acids help improve symptoms of ADHD have found mixed results. A few studies have found that omega-3 fatty acids helped improve behavioral symptoms, but most were not well designed. One study that looked at DHA in addition to stimulant therapy (standard therapy for ADHD) found no effect. More research is needed, but eating foods that are high in omega-3 fatty acids is a reasonable approach for someone with ADHD.
A number of studies show that reduced intake of omega-3 fatty acids is associated with increased risk of age related cognitive decline or dementia, including Alzheimer’s disease. Scientists believe the omega-3 fatty acid DHA is protective against Alzheimer’s disease and dementia.
In one clinical study, 13 people with sun sensitivity known as photo dermatitis showed less sensitivity to UV rays after taking fish oil supplements. Revealed after was that topical sunscreens are much better at protecting the skin from damaging effects of the sun than omega-3 fatty acids.
In another study of 40 people with psoriasis, those who took EPA with their prescription medications did better than those treated with the medications alone. Conclusively, a larger study of people with psoriasis found no benefit from fish oil but not with YTE supplementation where Laminine have worked to several patients with skin problems such as psoriasis.
Results are mixed as to whether omega-3 fatty acids can help reduce symptoms of Crohn’s disease and ulcerative colitis, the 2 types of IBD. Some studies suggest that omega-3 fatty acids may help when added to medication, such as sulfasalazine (a standard medication for IBD). Others find no effect. More studies are needed. Fish oil supplements can cause side effects that are similar to symptoms of IBD (such as flatulence, belching, bloating, and diarrhea).
Studies examining omega-3 fatty acids for asthma are mixed. In one small, well designed clinical study of 29 children with asthma, those who took fish oil supplements rich in EPA and DHA for 10 months reduced their symptoms compared to children who took placebo. However, most studies have shown no effect.
A questionnaire given to more than 3,000 people over the age of 49 found that those who ate more fish were less likely to have macular degeneration (a serious age related eye condition that can progress to blindness) than those who ate less fish. Similarly, a clinical study comparing 350 people with macular degeneration to 500 without the eye disease found that those with a healthy dietary balance of omega-3 and omega-6 fatty acids and more fish in their diets were less likely to have macular degeneration.
In one study of 42 women, they had less menstrual pain when they took fish oil supplements than when they took placebo. But as of 2016 testimonials gathered, very few have said it worked for their menstrual cramps.
Eating foods rich in omega-3 fatty acids seems to reduce the risk of colorectal cancer. For example, Eskimos, who tend to have a high fat diet, but eat significant amounts of fish rich in omega-3 fatty acids, have a low rate of colorectal cancer. Animal studies and laboratory studies have found that omega-3 fatty acids prevent worsening of colon cancer. Preliminary studies suggest that taking fish oil daily may help slow the progression of colon cancer in people with early stages of the disease. If you have colorectal cancer, ask your doctor before taking any supplements.
Although not all experts agree, women who eat foods rich in omega-3 fatty acids over many years may be less likely to develop breast cancer. More research is needed to understand the effect that omega-3 fatty acids may have on the prevention of breast cancer.
Population based studies of groups of men suggest that a low fat diet including omega-3 fatty acids from fish or fish oil help prevent the development of prostate cancer.
“My husband and I started taking Laminine in June 2013 and then Laminine OMEGA+++ in December 2013. Now he sleeps very well and his mood has improved. I feel very happy and have less stress in my life. Each day we feel better and younger (we are in our 60s). I’m so happy we have these products and I continue to share with friends and relatives the opportunity to have excellent health and wealth.” – Tatyana S., U.S.A.
“I’d been taking Laminine OMEGA+++ for a month and decided to check on the status of my cardiovascular and circulatory system. All tests came back with positive results—the ‘age’ of my vascular system came back as 48 when in fact I’m 64! I was really stunned and delighted!” – Galina A., U.S.A.
“Since taking Laminine OMEGA+++, I’ve experienced a noticeable improvement in my health! Taking it with Laminine, I have improved focus and energy.” – Lacie M., U.S.A.
“I took my first two Laminine OMEGA+++ capsules before bed and woke up the next morning feeling so blissful. I had such clarity that day and much more energy. I am aware of my body using it in my brain and now I’m wondering how else it will help!” – Karen S., Australia
“The LifePharm Global Network corporate family has given me a wonderful experience and opportunity. With these miraculous products, I look forward to improving my business achievement, which is also my small way of showing gratitude for what it has done for me.” – Dave S., Philippines
“I have about 15 years of experience with dietary supplements, but the results I have seen with Laminine are the fastest and the most significant. My 73-year-old father and my children have all benefited from both Laminine and Laminine OMEGA+++. My father feels a difference in his stamina and circulation, and my children are better able to retain what they learn at school.” – Timur S., U.S.A.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Results will vary depending on the facts and circumstances of each person. If you have concerns, please consult your physician.